Isolation of Antimalarial Agents From Indonesian Medicinal Plants: <i>Swietenia mahagoni</i> and <i>Pluchea indica</i>

Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into Indonesian medicinal plants Swietenia mahagoni Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri- O-caffeoylquinic acid (4) be most active against Plasmodium falciparum 3D7 Dd2 strains with IC 50 values of 8.2 8.8 µM, respectively. No cytotoxicity was observed Human Embryonic Kidney cells at concentration 40 µM.